Question: Are some people naturally just weak and susceptible to illnesses without an actual condition because of DNA sequence?

Andrew Senior answered on 25 Nov 2025:

Yes. But your question has a slight contradiction. If you have poor health because of a genetic mutation. This can be defined as a genetic disorder (condition). One example SCID (severe combined immunodeficiency). Mutations in genes like the JAK3 gene or IL2RG gene can cause a lifelong shortage of white blood cells. Since white blood cells are very important for fighting infection. This can make minor illness almost life-threatening for people with SCID. Another disorder is CVID (common variable immunodeficiency) and can be caused by a range of mutations. People who suffer from CVID suffer from frequent and recurrent bacterial and viral infections.